There are six uncapped players in the travelling party, while hooker Dewi Lake has been given the captaincy.
Lake leads the 33-man squad in the absence of flanker Jac Morgan, who is with the British and Irish Lions in Australia along with Gloucester scrum-half Tomos Williams.
Cardiff captain Liam Belcher, Dragons prop Chris Coleman, Ospreys trio Garyn Phillips, Keelan Giles and Reuben Morgan-Williams and Scarlets back Macs Page are the fresh faces in Japan.
Dragons second row Ben Carter, Scarlets fly-half Sam Costelow and Bath tight-head prop Archie Griffin return for Wales having missed the Six Nations due to injury, while Kieran Hardy, Alex Mann, Josh Macleod, James Ratti, Johnny Williams and Cameron Winnett have been handed recalls.
Cardiff number eight and Wales centurion Taulupe Faletau will provide experience alongside the likes of Josh Adams, Nicky Smith, Aaron Wainwright and Elliot Dee, who are the four survivors from the squad which went to the 2019 World Cup in Japan.
Some notable absentees are Dafydd Jenkins, Adam Beard, Will Rowlands, Henry Thomas, Ellis Mee, Gareth Anscombe, Max Llewellyn, Nick Tompkins, James Botham, Evan Lloyd and Morgan Morse, who are missing due to a combination of injuries, being rested and non-selection.
Forwards: Nicky Smith, Gareth Thomas, Garyn Phillips, Keiron Assiratti, Chris Coleman, Archie Griffin, Dewi Lake (capt), Liam Belcher, Elliot Dee, Ben Carter, Teddy Williams, Freddie Thomas, James Ratti, Taine Plumtree, Aaron Wainwright, Alex Mann, Taulupe Faletau, Tommy Reffell, Josh Macleod.
Backs: Kieran Hardy, Reuben Morgan-Williams, Rhodri Williams, Sam Costelow, Dan Edwards, Ben Thomas, Johnny Williams, Joe Roberts, Macs Page, Josh Adams, Tom Rogers, Blair Murray, Keelan Giles, Cameron Winnett.
